Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 10/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047860 | 0.83 | TP53 (0.38) | HSD17B10TP53JAK2TLR9POLB | |
| SCHEMBL8045937 | 0.81 | TP53 (0.38) | HSD17B10TP53JAK2TLR9POLB | |
| SCHEMBL8045476 | 0.80 | KMT2A (0.40) | HSD17B10TP53JAK2TLR9FBP1 | |
| SCHEMBL8045872 | 0.79 | FBP1 (0.40) | HSD17B10TP53JAK2TLR9FBP1 | |
| SCHEMBL8032540 | 0.78 | ALDH1A1 (0.53) | HSD17B10TP53POLBALDH1A1NPSR1 | |
| SCHEMBL8043575 | 0.78 | USP7 (0.36) | HSD17B10TP53JAK2TLR9POLB | |
| SCHEMBL8046990 | 0.77 | ALDH1A1 (0.47) | HSD17B10TP53FBP1PDK1POLB | |
| SCHEMBL8050933 | 0.77 | LMNA (0.40) | HSD17B10TP53JAK2TLR9POLB | |
| SCHEMBL8042172 | 0.77 | ALDH1A1 (0.38) | HSD17B10TP53JAK2TLR9ALDH1A1 | |
| SCHEMBL8044330 | 0.77 | MAPK8 (0.43) | TLR9ALDH1A1NPSR1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |