Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046039 | 0.94 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8044756 | 0.91 | ALDH1A1 (0.47) | HSP90AA1HSP90AB1ALDH1A1TSHRHPGD | |
| SCHEMBL8048089 | 0.83 | HSP90AA1 (0.57) | HSP90AA1HSP90AB1ALDH1A1TSHRHPGD | |
| SCHEMBL8051988 | 0.81 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8047839 | 0.81 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1ALDH1A1LMNAMAPT | |
| SCHEMBL8032720 | 0.79 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALDH1A1TSHRHPGD | |
| SCHEMBL8050909 | 0.79 | HSP90AA1 (0.48) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8033771 | 0.79 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1ALDH1A1TSHRHPGD | |
| SCHEMBL8034257 | 0.78 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8038020 | 0.77 | P2RX7 (0.44) | HSP90AA1HSP90AB1ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |