Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032815 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8044963 | 0.85 | ALDH1A1 (0.42) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8043945 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8042731 | 0.84 | ALDH1A1 (0.41) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8042535 | 0.82 | PTGS2 (0.44) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8034319 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8049946 | 0.81 | ALOX5 (0.47) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8032329 | 0.81 | RECQL (0.53) | SMN1; SMN2HTTALDH1A1LMNAMAPT | |
| SCHEMBL8051272 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2HTTKDM4EALDH1A1LMNA | |
| SCHEMBL8047518 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |