Sialic Acid

Sialic Acid

SCHEMBL804644

CC(=O)NC1C(O)CC(O)(C(=O)O)OC1[C@H](O)[C@H](O)CO

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NANP Q8TBE9 3/20 0.72
L3MBTL1 Q9Y468 1/20 0.68
NEU2 Q9Y3R4 3/20 0.47
NEU4 Q8WWR8 2/20 0.47
NEU3 Q9UQ49 2/20 0.47
NEU1 Q99519 1/20 0.47
SELL P14151 1/20 0.43
SELP P16109 1/20 0.43
MAG P20916 2/20 0.42
SIGLEC7 Q9Y286 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sialic Acid SCHEMBL22412 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL12391269 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22879166 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL20299824 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL23366253 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL24274184 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22279106 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL21067569 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL22943658 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3
Sialic Acid SCHEMBL16802838 1.00 NANP (0.72) NANPL3MBTL1NEU2NEU4NEU3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023239906-A2 SIALIC ACID DERIVATIVES AND METHODS OF USING SAME EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-12-14 WO disclosed
US-11246878-B2 Compositions and products for infectious or inflammatory diseases or conditions B&H BIOTECHNOLOGIES, LLC (US) 2022-02-15 US disclosed
US-20160200795-A1 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII NOVO NORDISK A/S (DK) 2016-07-14 US disclosed
US-9034844-B2 6′-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides INALCO S.P.A. (IT) 2015-05-19 US disclosed
WO-2014151523-A1 COMPOSITIONS AND PRODUCTS FOR INFECTIOUS OR INFLAMMATORY DISEASES OR CONDITIONS WANG HUIRU (US) 2014-09-25 WO disclosed
US-8658093-B2 Devices and methods for the detection of analytes APPLIED BIOSYSTEMS, LLC (US) 2014-02-25 US disclosed
US-8658093-B2 Devices and methods for the detection of analytes APPLIED BIOSYSTEMS, LLC (US) 2014-02-25 US disclosed
US-20120071441-A1 6'-SIALYLLACTOSE SALTS AND PROCESS FOR THEIR SYNTHESIS AND FOR THE SYNTHESIS OF OTHER ALPHA-SIALYLOLIGOSACCHARIDES INALCO S.P.A. (IT) 2012-03-22 US disclosed
US-8076292-B2 Factor VIII: remodeling and glycoconjugation of factor VIII NOVO NORDISK A/S (DK) 2011-12-13 US disclosed
US-8063015-B2 Glycopegylation methods and proteins/peptides produced by the methods NOVO NORDISK A/S (DK) 2011-11-22 US disclosed
US-20080050772-A1 Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF NEOSE TECHNOLOGIES, INC. (US) 2008-02-28 US disclosed
US-7297511-B2 Viricides; heptatis virus; complexing of interferon with glycan NEOSE TECHNOLOGIES, INC. (US) 2007-11-20 US disclosed
US-7276475-B2 Remodeling and glycoconjugation of peptides NEOSE TECHNOLOGIES, INC. (US) 2007-10-02 US disclosed
US-7265084-B2 Glycopegylation methods and proteins/peptides produced by the methods NEOSE TECHNOLOGIES, INC. (US) 2007-09-04 US disclosed
US-7265085-B2 Glycoconjugation methods and proteins/peptides produced by the methods NEOSE TECHNOLOGIES, INC. (US) 2007-09-04 US disclosed
US-7226903-B2 Interferon beta: remodeling and glycoconjugation of interferon beta NEOSE TECHNOLOGIES, INC. (US) 2007-06-05 US disclosed
US-7214660-B2 Erythropoietin: remodeling and glycoconjugation of erythropoietin NEOSE TECHNOLOGIES, INC. (US) 2007-05-08 US disclosed
US-7179617-B2 Forming a convalent conjugate of a Factor IX peptide, removing X2 or a saccharyl subunit thereof from peptide forming a truncated glycan; contacting truncated glycan with glycosyltransferase and modified sugar donor under conditions suitable for glycosyltransferase to transfer a modified sugar moiety NEOSE TECHNOLOGIES, INC. (US) 2007-02-20 US disclosed
US-20070027068-A1 Erythropoietin: remodeling and glycoconjugation of erythropoietin NOVO NORDISK A/S (DK) 2007-02-01 US disclosed
US-7157277-B2 Factor VIII remodeling and glycoconjugation of Factor VIII NEOSE TECHNOLOGIES, INC. (US) 2007-01-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11246878-B2 Compositions and products for infectious or inflammatory diseases or conditions SI, SLC5A1, FABP2 NANP 327/4885L3MBTL1 4696/4885NEU2 34/4885
US-20120071441-A1 6'-SIALYLLACTOSE SALTS AND PROCESS FOR THEIR SYNTHESIS AND FOR THE SYNTHESIS OF OTHER ALPHA-SIALYLOLIGOSACCHARIDES ST6GAL1, FUT6, ST3GAL3 NANP 127/4885L3MBTL1 3410/4885NEU2 12/4885
US-20160200795-A1 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII F13B, F8, F13A1 NANP 473/4885L3MBTL1 3461/4885NEU2 136/4885
US-20070027068-A1 Erythropoietin: remodeling and glycoconjugation of erythropoietin EPOR, HBG2, HAMP NANP 1534/4885L3MBTL1 4188/4885NEU2 316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.