SCHEMBL8046487

SCHEMBL8046487

Fc1cc(-c2ccc(CCC(C3CCCCC3)C3CCCCC3)cc2)cc(F)c1F

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 7/20 0.37
CTSC P53634 2/20 0.34
DPP4 P27487 1/20 0.33
HRH4 Q9H3N8 1/20 0.33
MAOB P27338 1/20 0.33
F10 P00742 1/20 0.32
CXCR4 P61073 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
BRS3 P32247 1/20 0.32
C3AR1 Q16581 1/20 0.31
CNR1 P21554 1/20 0.31
CNR2 P34972 1/20 0.31
CYP17A1 P05093 1/20 0.31
CYP21A2 P08686 1/20 0.31
CYP11B1 P15538 1/20 0.31
MME P08473 1/20 0.31
ACE P12821 1/20 0.31
CPA1 P15085 1/20 0.31
ACE2 Q9BYF1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8042938 0.91 RARB (0.35) HRH3CTSCDPP4HRH4MAOB
SCHEMBL28236690 0.89 CYP17A1 (0.41) HRH3DPP4HRH4TAAR1BRS3
SCHEMBL8042783 0.85 DPP4 (0.38) DPP4C3AR1
SCHEMBL8040010 0.80 ALDH1A1 (0.42) MAOBTAAR1
SCHEMBL8046295 0.79 ALDH1A1 (0.42) DPP4CNR1
SCHEMBL19720332 0.78 GPR84 (0.39) HRH3HRH4MAOBBRS3
SCHEMBL8042732 0.76 DPP4 (0.36) DPP4C3AR1
SCHEMBL8046386 0.75 DPP4 (0.36) DPP4C3AR1
SCHEMBL8040022 0.74 DPP4 (0.35) DPP4C3AR1
SCHEMBL8464214 0.73 EPHX1 (0.47) HRH3TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727473-B1 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-01-12 EP disclosed
US-5833879-A LOW TEMPERATURE MISCIBILITY AND COMPATIBILITY WITH OTHER LIQUID CRYSTAL COMPOUNDS; DISPLAYS CONTAINING MIXTURES OF AT LEAST TWO COMPOUNDS, PHYSICAL PROPERTIES CHISSO CORPORATION (JP) 1998-11-10 US disclosed
EP-0727473-A2 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element Chisso Corporation (JP) 1996-08-21 EP disclosed