Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 12/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032711 | 0.87 | FBP1 (0.40) | FBP1PDK1HTR7FDPSGABRA1 | |
| SCHEMBL8048705 | 0.83 | FBP1 (0.46) | FBP1PDK1HTR7FDPSGABRA1 | |
| SCHEMBL8051741 | 0.81 | GSK3B (0.39) | FBP1PDK1HTR7FDPSGABRA1 | |
| SCHEMBL8031756 | 0.81 | FBP1 (0.44) | FBP1PDK1HTR7FDPSGABRA1 | |
| SCHEMBL8042143 | 0.81 | POLB (0.42) | FBP1PDK1HTR7GABRA1GABRG2 | |
| SCHEMBL8033947 | 0.80 | F2 (0.45) | FBP1PDK1HTR7FDPSGABRA1 | |
| SCHEMBL8043809 | 0.80 | FBP1 (0.42) | FBP1PDK1HTR7GABRA1GABRG2 | |
| SCHEMBL8032531 | 0.79 | APEX1 (0.37) | FBP1PDK1FDPSALDH1A1 | |
| SCHEMBL8048610 | 0.77 | ALDH1A1 (0.46) | FBP1PDK1ALDH1A1TSHR | |
| SCHEMBL8045795 | 0.76 | ATM (0.48) | FBP1PDK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |