Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064071 | 0.84 | AKR1B1 (0.41) | PPARGPPARAALDH1A1SRC | |
| SCHEMBL5051096 | 0.81 | ACP3 (0.54) | ALDH1A1 | |
| SCHEMBL5054709 | 0.81 | ACP3 (0.44) | SRC | |
| SCHEMBL8061504 | 0.81 | KLK7 (0.41) | PPARGPPARAALDH1A1MEN1KMT2A | |
| SCHEMBL5060095 | 0.77 | FOLH1 (0.41) | PPARGPPARAALDH1A1MEN1KMT2A | |
| SCHEMBL5054362 | 0.76 | HPGDS (0.38) | GAAMEN1KMT2APOLB | |
| SCHEMBL5052757 | 0.76 | PPARA (0.43) | PPARGPPARAALDH1A1POLBSRC | |
| SCHEMBL5054488 | 0.76 | SMN1; SMN2 (0.50) | ALDH1A1GAAMEN1KMT2AFNTA | |
| SCHEMBL8058398 | 0.75 | PKM (0.48) | PPARGPPARAMEN1KMT2A | |
| SCHEMBL5051263 | 0.75 | LMNA (0.41) | GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |