Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046811 | 0.84 | PPARG (0.40) | SRCPPARGPPARAALDH1A1 | |
| SCHEMBL5051096 | 0.82 | ACP3 (0.54) | TSHRACP3KDM4EALDH1A1 | |
| SCHEMBL5054709 | 0.82 | ACP3 (0.44) | TSHRSRCACP3HPGD | |
| SCHEMBL5054362 | 0.80 | HPGDS (0.38) | TSHRACP3LMNAKDM4E | |
| SCHEMBL5054488 | 0.79 | SMN1; SMN2 (0.50) | TSHRLMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5052757 | 0.77 | PPARA (0.43) | SRCACP3LMNAPPARGPPARA | |
| SCHEMBL5058000 | 0.77 | FOLH1 (0.42) | AKR1B1TSHRALDH1A1 | |
| SCHEMBL8058398 | 0.76 | PKM (0.48) | PPARGPPARAKDM4E | |
| SCHEMBL5051263 | 0.76 | LMNA (0.41) | TSHRLMNAKDM4EHSD17B10 | |
| SCHEMBL8061504 | 0.76 | KLK7 (0.41) | PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |