Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.36 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 5/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752801 | 0.89 | SYK (0.41) | ALDH1A1MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL23768365 | 0.80 | SOAT1 (0.49) | TLR8 | |
| SCHEMBL14294339 | 0.79 | HCAR3 (0.42) | ALDH1A1HPGDTLR8SMN1; SMN2TP53 | |
| SCHEMBL6861106 | 0.78 | MAPT (0.52) | HRH3ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL13390761 | 0.78 | HRH3 (0.45) | HRH3ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL20037454 | 0.77 | IL1B (0.45) | ALDH1A1MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL15382053 | 0.74 | HCAR3 (0.46) | ALDH1A1HPGDHSD17B10SMN1; SMN2TP53 | |
| SCHEMBL10356814 | 0.74 | CYP2C19 (0.50) | HRH3 | |
| SCHEMBL12895618 | 0.74 | HCAR3 (0.39) | ALDH1A1HSD17B10SMN1; SMN2TP53NPC1 | |
| SCHEMBL1629798 | 0.73 | HRH3 (0.51) | HRH3ALDH1A1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100268-A | MIGRAINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-08 | — | — | US | disclosed |
| CN-1052006-C | Dihydrobenzopyran derivatives as vasoconstrictors, preparation and use thereof | JANSSEN PHARMACEUTICA NV (NL) | 2000-05-03 | — | — | CN | disclosed |
| US-5824682-A | Vasoconstrictive dihydrobenzopyran derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-10-20 | — | — | US | disclosed |
| CN-1129451-A | Dihydrobenzopyran derivatives as vasoconstrictors | JANSSEN PHARMACEUTICA NV (BE) | 1996-08-21 | — | — | CN | disclosed |