Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047355 | 0.82 | ALDH1A1 (0.50) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL28531282 | 0.75 | LMNA (0.43) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL18570343 | 0.74 | SLC6A2 (0.45) | ADRA2BHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL10709666 | 0.73 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL30587766 | 0.73 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL220092 | 0.73 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL24827553 | 0.70 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL17877183 | 0.70 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL9440903 | 0.70 | ALDH1A1 (0.49) | ADRA2AADRA2BADRA2CHPGDKMT2A | |
| SCHEMBL3160283 | 0.70 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297133-B1 | 1, 2 DISUBSTITUTED HETEROCYCLIC COMPOUNDS | FORUM PHARMACEUTICALS INC (US) | 2017-09-13 | — | — | EP | disclosed |