SCHEMBL8047995

SCHEMBL8047995

CC=C(C(=O)OC)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
NR4A1 P22736 1/20 0.47
NR4A2 P43354 1/20 0.47
NR4A3 Q92570 1/20 0.47
CYP1A1 P04798 2/20 0.46
CYP1B1 Q16678 2/20 0.46
MAOB P27338 1/20 0.46
TRPV1 Q8NER1 2/20 0.45
SRD5A2 P31213 1/20 0.44
CFTR P13569 1/20 0.44
PTPN1 P18031 2/20 0.44
AKR1C3 P42330 1/20 0.43
GSK3B P49841 2/20 0.43
ALDH1A1 P00352 1/20 0.43
NPSR1 Q6W5P4 1/20 0.42
LSS P48449 1/20 0.42
KDM4E B2RXH2 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14638744 0.81 CYP1A1 (0.42) CES2CES1NR4A1NR4A2NR4A3
SCHEMBL14638745 0.81 CYP1A1 (0.42) CES2CES1NR4A1NR4A2NR4A3
SCHEMBL8058346 0.80 AKR1C3 (0.57) CES2CES1NR4A1NR4A2NR4A3
SCHEMBL10441841 0.80 CES2 (0.67) CES2CES1NR4A1NR4A2NR4A3
SCHEMBL22505774 0.79 NPC1 (0.47) CES2CES1NR4A1NR4A2NR4A3
SCHEMBL9432437 0.78 MAPT (0.61) ALDH1A1KDM4EHTTKMT2A
SCHEMBL9432571 0.78 CA1 (0.50) SRD5A2ALDH1A1KDM4EHTTKMT2A
SCHEMBL8061017 0.78 ALDH1A1 (0.56) CES2CES1SRD5A2ALDH1A1NPSR1
SCHEMBL19309865 0.77 CES2 (0.52) CES2CES1NR4A1NR4A2NR4A3
SCHEMBL9299166 0.77 CES2 (0.52) CES2CES1NR4A1NR4A2NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127392-A A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 US disclosed
EP-1003712-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-31 EP disclosed
US-6046239-A USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE AMERICAN HOME PRODUCTS CORPORATION (US) 2000-04-04 US disclosed
WO-1999007669-A1 ANTHRANILIC ACID ANALOGS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-02-18 WO disclosed