Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048414 | 0.87 | LMNA (0.36) | ALDH1A1HSD17B10GABRA5GABRB2LMNA | |
| SCHEMBL8043591 | 0.84 | KMT2A (0.37) | ALDH1A1HSD17B10GABRA5GABRB2LMNA | |
| SCHEMBL8051292 | 0.83 | CYP1A2 (0.38) | ALDH1A1HSD17B10GABRA5GABRB2LMNA | |
| SCHEMBL8041793 | 0.83 | POLB (0.43) | ALDH1A1HSD17B10GABRA5GABRB2LMNA | |
| SCHEMBL8051833 | 0.81 | POLB (0.54) | ALDH1A1HSD17B10LMNAPOLBSMN1; SMN2 | |
| SCHEMBL8048135 | 0.80 | ALDH1A1 (0.37) | ALDH1A1HSD17B10GABRA5GABRB2LMNA | |
| SCHEMBL8043087 | 0.78 | ALDH1A1 (0.36) | ALDH1A1HSD17B10LMNAPOLBSMN1; SMN2 | |
| SCHEMBL8034317 | 0.78 | HPGD (0.51) | ALDH1A1HSD17B10LMNAPOLBSMN1; SMN2 | |
| SCHEMBL8050384 | 0.77 | HTT (0.38) | ALDH1A1HSD17B10LMNASMN1; SMN2TP53 | |
| SCHEMBL8044691 | 0.77 | HSD17B10 (0.36) | ALDH1A1HSD17B10GABRA5GABRB2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |