Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051833 | 0.85 | POLB (0.54) | POLBHSD17B10ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL8048121 | 0.83 | ALDH1A1 (0.36) | POLBHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL8043765 | 0.83 | L3MBTL1 (0.41) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL8048414 | 0.83 | LMNA (0.36) | POLBHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL8048131 | 0.81 | MAPK1 (0.43) | POLBHSD17B10ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL8044691 | 0.81 | HSD17B10 (0.36) | POLBHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL8043692 | 0.81 | HSD17B10 (0.36) | POLBHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL8034317 | 0.80 | HPGD (0.51) | POLBHSD17B10ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8041793 | 0.80 | POLB (0.43) | POLBHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL8048242 | 0.80 | HSD17B10 (0.37) | POLBHSD17B10GABRA5GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |