Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048121 | 0.84 | ALDH1A1 (0.36) | KMT2AMEN1POLBHPGDALDH1A1 | |
| SCHEMBL8048414 | 0.84 | LMNA (0.36) | KMT2AMEN1POLBHPGDALDH1A1 | |
| SCHEMBL8047853 | 0.81 | KMT2A (0.40) | KMT2AMEN1POLBHPGDALDH1A1 | |
| SCHEMBL8049863 | 0.80 | MAPT (0.43) | KMT2AMEN1POLBHPGDALDH1A1 | |
| SCHEMBL8051292 | 0.79 | CYP1A2 (0.38) | KMT2AMEN1POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8051833 | 0.78 | POLB (0.54) | KMT2AMEN1POLBHPGDALDH1A1 | |
| SCHEMBL8043929 | 0.78 | MAPK8 (0.47) | KMT2AMEN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8048135 | 0.77 | ALDH1A1 (0.37) | KMT2AMEN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL8051983 | 0.77 | MAPT (0.39) | KMT2AMEN1POLBHPGDALDH1A1 | |
| SCHEMBL8045804 | 0.77 | KDM1A (0.39) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |