Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MGAM | O43451 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | SI | P14410 | 6/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045150 | 0.83 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8050866 | 0.83 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8042032 | 0.83 | HSP90AA1 (0.40) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8043870 | 0.82 | PDK1 (0.49) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8042678 | 0.82 | CSNK1D (0.48) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8044261 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8033852 | 0.81 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2L3MBTL1TSHRLMNA | |
| SCHEMBL8043423 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8050306 | 0.80 | LMNA (0.41) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 | |
| SCHEMBL8049808 | 0.79 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2L3MBTL1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |