Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8713674 | 0.94 | LMNA (0.40) | LMNASMN1; SMN2MAPK1MAPTRAB9A | |
| SCHEMBL8045832 | 0.90 | LMNA (0.42) | LMNASMN1; SMN2MAPK1MAPTRAB9A | |
| SCHEMBL8048583 | 0.86 | ALDH1A1 (0.45) | LMNASMN1; SMN2MAPK1RAB9AHTT | |
| SCHEMBL8043763 | 0.84 | ALDH1A1 (0.40) | LMNASMN1; SMN2MAPK1MAPTHTT | |
| SCHEMBL8032682 | 0.82 | TSHR (0.45) | LMNASMN1; SMN2MAPK1RAB9AHTT | |
| SCHEMBL8043688 | 0.82 | HTR1A (0.46) | LMNASMN1; SMN2MAPK1MAPTRAB9A | |
| SCHEMBL8034187 | 0.80 | HTR1A (0.44) | LMNASMN1; SMN2MAPK1MAPTRAB9A | |
| SCHEMBL8044696 | 0.80 | HTT (0.40) | LMNASMN1; SMN2MAPK1MAPTRAB9A | |
| SCHEMBL8046147 | 0.80 | ALDH1A1 (0.42) | LMNASMN1; SMN2MAPK1MAPTRAB9A | |
| SCHEMBL8048145 | 0.80 | ALDH1A1 (0.55) | LMNASMN1; SMN2MAPK1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |