Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.54 |
| ▸ | CCR1 | P32246 | 1/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.48 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699256 | 0.90 | S1PR1 (0.45) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL11211964 | 0.87 | OPRM1 (0.45) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL4274774 | 0.85 | S1PR1 (0.46) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL10373872 | 0.84 | CCR1 (0.50) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL19710571 | 0.83 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4OPRM1 | |
| SCHEMBL7699254 | 0.82 | L3MBTL1 (0.46) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL16137355 | 0.82 | S1PR1 (0.50) | S1PR1S1PR3S1PR5S1PR4GNAI3 | |
| SCHEMBL10880730 | 0.80 | S1PR1 (0.44) | S1PR1S1PR3S1PR5S1PR4OPRM1 | |
| SCHEMBL1575025 | 0.79 | OPRD1 (0.43) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL4437885 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831087-B1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 2000-06-21 | — | — | EP | disclosed |
| US-5908935-A | Process for the preparation of 1-Acyl-4-arylpiperidines | LONZA AG (CH) | 1999-06-01 | — | — | US | disclosed |
| US-5789596-A | NEUROKININ RECEPTOR ANTAGONIST | LONZA AG (CH) | 1998-08-04 | — | — | US | disclosed |
| EP-0831087-A1 | Process for the preparation of 1-acyl-4-arylpiperidines | LONZA AG (CH) | 1998-03-25 | — | — | EP | disclosed |