Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048581 | 0.85 | S1PR1 (0.54) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL7699254 | 0.82 | L3MBTL1 (0.46) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL7699256 | 0.80 | S1PR1 (0.45) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL11211964 | 0.77 | OPRM1 (0.45) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL10373872 | 0.75 | CCR1 (0.50) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL12897872 | 0.73 | PAOX (0.54) | MAPTKMT2A | |
| SCHEMBL4782236 | 0.72 | OPRM1 (0.49) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL19710571 | 0.70 | S1PR1 (0.57) | S1PR1S1PR3S1PR5S1PR4OPRM1 | |
| SCHEMBL1575025 | 0.70 | OPRD1 (0.43) | S1PR1S1PR3S1PR5CCR1S1PR4 | |
| SCHEMBL4437885 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156637-A1 | BUTYROPHENONES AND SIGMA-1 RECEPTOR ANTAGONISTS PROTECT AGAINST OXIDATIVE-STRESS | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER OF FORT WORTH (US) | 2009-06-18 | — | — | US | disclosed |
| US-20060106064-A1 | Butyrophenones and sigma-1 receptor antagonists protect against oxidative-stress | UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH (US) | 2006-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156637-A1 | BUTYROPHENONES AND SIGMA-1 RECEPTOR ANTAGONISTS PROTECT AGAINST OXIDATIVE-STRESS | SIGMAR1, OPRK1, OPRL1 | S1PR1 773/4885S1PR3 902/4885S1PR5 1688/4885 |
| US-20060106064-A1 | Butyrophenones and sigma-1 receptor antagonists protect against oxidative-stress | SIGMAR1, OPRK1, OPRL1 | S1PR1 773/4885S1PR3 902/4885S1PR5 1688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.