Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | ESR1 | P03372 | 5/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048425 | 1.00 | LMNA (0.56) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL1688726 | 0.87 | ESR1 (0.59) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8038305 | 0.84 | ESR1 (0.71) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL19236350 | 0.84 | ESR1 (0.71) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8667705 | 0.84 | ESR1 (0.71) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8038391 | 0.84 | ESR1 (0.71) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8055650 | 0.83 | LMNA (0.43) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8049873 | 0.82 | PPARD (0.42) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8049867 | 0.82 | PPARD (0.42) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8048882 | 0.82 | PPARD (0.42) | LMNAHSD17B10ESR1ESR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882735-B1 | 9 Alpha-hydroxy-8 alpha-estra-1,3,5(10)-trienes and a process for their preparation | JENAPHARM GMBH (DE) | 2000-04-19 | — | — | EP | disclosed |
| EP-0882735-A1 | 9 Alpha-hydroxy-8 alpha-estra-1,3,5(10)-trienes and a process for their preparation | Jenapharm GmbH & Co. KG (DE) | 1998-12-09 | — | — | EP | disclosed |