Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | DRD3 | P35462 | 6/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052780 | 0.84 | PPARD (0.41) | LMNAKDM1AESR1CYP2C19MAPT | |
| SCHEMBL8048890 | 0.83 | LMNA (0.56) | LMNAHSD17B10KDM1AESR1ESR2 | |
| SCHEMBL8048425 | 0.83 | LMNA (0.56) | LMNAHSD17B10KDM1AESR1ESR2 | |
| SCHEMBL8038058 | 0.78 | HSD17B1 (0.44) | LMNAKDM1ACYP2C19CYP3A4CYP26A1 | |
| SCHEMBL8048295 | 0.74 | STS (0.60) | LMNAHSD17B10ESR1ESR2CYP3A4 | |
| SCHEMBL11222251 | 0.74 | STS (0.60) | LMNAHSD17B10ESR1ESR2CYP3A4 | |
| SCHEMBL11671496 | 0.74 | STS (0.60) | LMNAHSD17B10ESR1ESR2CYP3A4 | |
| SCHEMBL11672711 | 0.74 | LMNA (0.71) | LMNAHSD17B10ESR1ESR2CYP2C19 | |
| SCHEMBL5166260 | 0.74 | LMNA (0.71) | LMNAHSD17B10ESR1ESR2CYP2C19 | |
| SCHEMBL11860032 | 0.74 | LMNA (0.71) | LMNAHSD17B10ESR1ESR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882735-B1 | 9 Alpha-hydroxy-8 alpha-estra-1,3,5(10)-trienes and a process for their preparation | JENAPHARM GMBH (DE) | 2000-04-19 | — | — | EP | disclosed |
| EP-0882735-A1 | 9 Alpha-hydroxy-8 alpha-estra-1,3,5(10)-trienes and a process for their preparation | Jenapharm GmbH & Co. KG (DE) | 1998-12-09 | — | — | EP | disclosed |