Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CPB1 | P15086 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044411 | 0.88 | KMT2A (0.55) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8052209 | 0.85 | ALDH1A1 (0.53) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8033820 | 0.84 | ALDH1A1 (0.49) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8041923 | 0.83 | PDK1 (0.47) | KMT2AMEN1HPGDALDH1A1MAPT | |
| SCHEMBL8042814 | 0.83 | PTGS2 (0.40) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8047485 | 0.82 | HPGD (0.47) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8043106 | 0.82 | MEN1 (0.45) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8032703 | 0.81 | KMT2A (0.44) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8048432 | 0.81 | MEN1 (0.47) | KMT2AMEN1HPGDALDH1A1TP53 | |
| SCHEMBL8042553 | 0.80 | HPGD (0.48) | KMT2AMEN1HPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |