Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ILK | Q13418 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033856 | 0.85 | PKM (0.46) | PKMALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8047478 | 0.83 | PKM (0.44) | PKMALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8043670 | 0.83 | PKM (0.44) | PKMALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8045105 | 0.82 | ALDH1A1 (0.40) | PKMALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8050953 | 0.82 | PDK1 (0.56) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL8033160 | 0.81 | PKM (0.51) | PKMALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL8042747 | 0.81 | PKM (0.42) | PKMALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8052304 | 0.81 | ALDH1A1 (0.49) | PKMALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8042755 | 0.80 | HCAR3 (0.44) | ALDH1A1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL8043976 | 0.79 | KDM4E (0.43) | PKMALDH1A1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |