Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13587136 | 0.82 | CASR (0.33) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL10183352 | 0.81 | RAB9A (0.50) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL21981998 | 0.78 | ACACB (0.36) | SMN1; SMN2NPC1RAB9ATRPV1 | |
| SCHEMBL7920616 | 0.77 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL25604320 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL16624932 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL24910454 | 0.72 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL14046218 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL18258326 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL4384430 | 0.71 | SMN1; SMN2 (0.85) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071475-A1 | UREA DERIVATIVES HAVING PI3K-INHIBITING ACTIVITY | MTOR, STAT3, SLC14A1 | SMN1; SMN2 3011/4885ALDH1A1 3750/4885NPC1 1283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.