Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045631 | 0.88 | HDAC6 (0.39) | HDAC6ALOX5MEN1KMT2AALDH1A1 | |
| SCHEMBL8044965 | 0.86 | OPRM1 (0.43) | HDAC6CYP3A4CYP2C9KCNH2RAB9A | |
| SCHEMBL8045183 | 0.86 | OPRM1 (0.43) | HDAC6CYP3A4CYP2C9KCNH2RAB9A | |
| SCHEMBL8049980 | 0.85 | HDAC6 (0.50) | HDAC6ALOX5CYP3A4KCNH2HDAC1 | |
| SCHEMBL8052916 | 0.84 | HDAC6 (0.41) | HDAC6CYP3A4CYP2C9KCNH2TSHR | |
| SCHEMBL8035219 | 0.84 | ALOX5 (0.39) | ALOX5ALDH1A1CES1KCNA3PLA2G4A | |
| SCHEMBL8045765 | 0.81 | CCR1 (0.40) | HDAC6CYP3A4CYP2C9KCNH2HDAC1 | |
| SCHEMBL8049785 | 0.78 | HDAC1 (0.37) | HDAC6ALDH1A1CYP3A4CYP2C9KCNH2 | |
| SCHEMBL8050105 | 0.77 | HDAC3 (0.38) | HDAC6KMT2AALDH1A1HDAC1LMNA | |
| SCHEMBL8044769 | 0.76 | GAA (0.39) | HDAC6HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749957-B1 | Aromatic hydroxamic acid compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0749957-A1 | Aromatic hydroxamic acid compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1996-12-27 | — | — | EP | disclosed |