Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047618 | 0.89 | RAB9A (0.46) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8048046 | 0.84 | MAPT (0.47) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8051792 | 0.82 | AR (0.43) | KMT2ASMN1; SMN2NPC1RAB9AKDM4E | |
| SCHEMBL8044982 | 0.81 | MAPT (0.44) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8044036 | 0.80 | KMT2A (0.44) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8046628 | 0.80 | AR (0.40) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8042402 | 0.79 | ALDH1A1 (0.40) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8044338 | 0.79 | POLB (0.44) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL8048213 | 0.79 | XPO1 (0.40) | KMT2AMEN1KDM4ELMNAMAPT | |
| SCHEMBL8042878 | 0.78 | HSD17B10 (0.42) | KMT2ASMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |