Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.36 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043900 | 0.83 | SMN1; SMN2 (0.36) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8042878 | 0.83 | HSD17B10 (0.42) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8047618 | 0.82 | RAB9A (0.46) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8033941 | 0.80 | SMN1; SMN2 (0.36) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8049804 | 0.79 | KMT2A (0.43) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8044452 | 0.78 | RAB9A (0.44) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8051281 | 0.77 | MEN1 (0.39) | ALDH1A1MEN1KMT2ARECQLGAA | |
| SCHEMBL8042296 | 0.77 | RAB9A (0.39) | ALDH1A1MAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL8048213 | 0.77 | XPO1 (0.40) | ALDH1A1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL8042050 | 0.76 | LMNA (0.42) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |