Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045613 | 0.86 | RAB9A (0.44) | RAB9AHTTALDH1A1NPC1TDP1 | |
| SCHEMBL8032795 | 0.78 | HPGD (0.56) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8044077 | 0.78 | PPARG (0.44) | RAB9AALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL8047174 | 0.75 | RAB9A (0.47) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8032700 | 0.74 | HTR1A (0.49) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL4047725 | 0.73 | HTR1A (0.58) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8737914 | 0.73 | SREBF2 (0.59) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL10613520 | 0.72 | RAB9A (0.60) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL8042378 | 0.71 | HTR1A (0.47) | HTR1AHTR2AHTR7RAB9AHTT | |
| SCHEMBL155616 | 0.70 | RECQL (0.62) | RAB9AHTTSREBF2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |