Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033843 | 0.79 | ALOX5 (0.35) | PPARGMAPTNPSR1KMT2AEIF4E | |
| SCHEMBL8032725 | 0.78 | PPARG (0.44) | PPARGMAPTKMT2ARAB9ANPC1 | |
| SCHEMBL8050307 | 0.78 | HTR1A (0.47) | MAPTKMT2ARAB9ANPC1KDM4E | |
| SCHEMBL8042665 | 0.77 | MAPT (0.41) | PPARGMAPTKMT2AEIF4EALOX5 | |
| SCHEMBL8045613 | 0.75 | RAB9A (0.44) | MAPTKMT2AALOX5RAB9ANPC1 | |
| SCHEMBL8032747 | 0.75 | F2RL3 (0.37) | PPARGMAPTKMT2AEIF4EALOX5 | |
| SCHEMBL13997536 | 0.75 | MAPT (0.60) | MAPTKMT2AALOX5RAB9ANPC1 | |
| SCHEMBL8050819 | 0.74 | F2RL3 (0.36) | PPARGMAPTKMT2AEIF4EALOX5 | |
| SCHEMBL8050615 | 0.73 | ALOX5 (0.35) | PPARGMAPTKMT2AIKBKBEIF4E | |
| SCHEMBL8033766 | 0.73 | F2RL3 (0.36) | PPARGMAPTEIF4EALOX5CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |