Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CHKA | P35790 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19907842 | 0.83 | SIGMAR1 (0.40) | MC4RLMNAMAPT | |
| SCHEMBL12956814 | 0.80 | HRH3 (0.45) | KDM4ETDP1ALDH1A1POLBHRH4 | |
| SCHEMBL26193868 | 0.78 | ACHE (0.47) | ALDH1A1PRMT6 | |
| SCHEMBL22080014 | 0.78 | KMT2A (0.45) | LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL21418295 | 0.78 | HRH3 (0.34) | ALDH1A1 | |
| SCHEMBL14148728 | 0.77 | SIGMAR1 (0.44) | LMNATDP1ALDH1A1 | |
| SCHEMBL21337487 | 0.76 | OPRM1 (0.36) | — | |
| SCHEMBL14148582 | 0.75 | KDM4E (0.33) | KDM4E | |
| SCHEMBL13945588 | 0.74 | LTA4H (0.33) | — | |
| SCHEMBL12445779 | 0.74 | PARP1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3328853-B1 | SUBSTITUTED AMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS SA (ES) | 2019-09-11 | — | — | EP | disclosed |
| EP-2945943-B1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |
| WO-2009068246-A2 | METHODS OF TREATING OBESITY AND METABOLIC DISORDERS | ELBION GMBH (DE) | 2009-06-04 | — | — | WO | disclosed |