SCHEMBL8050878

SCHEMBL8050878

CCN(CC)P(O)OCCC#N

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5610478 0.85 TSHR (0.32) TSHR
SCHEMBL11842318 0.80
SCHEMBL9662674 0.79 CASP1 (0.32)
SCHEMBL2006419 0.79 TSHR (0.32) TSHR
SCHEMBL3396059 0.76 ALDH1A1 (0.34)
SCHEMBL7262903 0.74 TSHR (0.30) TSHR
SCHEMBL252367 0.74 TSHR (0.30) TSHR
SCHEMBL7858703 0.74 TSHR (0.30) TSHR
SCHEMBL21503839 0.74 TSHR (0.30) TSHR
Hydrochloric Acid SCHEMBL25380883 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230212178-A1 METHOD OF PRODUCING PHOTOREACTIVE NUCLEOTIDE ANALOG JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2023-07-06 US disclosed
CN-110719912-B Photoresponsive nucleotide analogs capable of photocrosslinking in the visible region 国立大学法人北陆先端科学技术大学院大学 2022-08-09 CN disclosed
CN-110914278-B Photoresponsive nucleotide analogs capable of photocrosslinking in the visible region 国立大学法人北陆先端科学技术大学院大学 2022-06-24 CN disclosed
EP-3660021-B1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECH (JP) 2022-01-19 EP disclosed
US-11214590-B2 Photoresponsive nucleotide analog capable of photocrosslinking in visible light region JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2022-01-04 US disclosed
US-11078211-B2 Photoresponsive nucleotide analog capable of photocrosslinking in visible light region JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2021-08-03 US disclosed
US-20200317685-A1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2020-10-08 US disclosed
US-20200172563-A1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2020-06-04 US disclosed
EP-3660022-A1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION Japan Advanced Institute of Science and Technology (JP) 2020-06-03 EP disclosed
EP-3660021-A1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION Japan Advanced Institute of Science and Technology (JP) 2020-06-03 EP disclosed
US-8912318-B2 Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids UNIVERSITY OF IDAHO (US) 2014-12-16 US disclosed
US-6018019-A IMMUNOGENIC SYNTHETIC PEPTIDES WHICH ARE USEFUL ALONE OR IN CONJUGATES IN VACCINES AGAINST HEMOPHILUS INFLUENZA INFECTION CONNAUGHT LABORATORIES LIMITED (CA) 2000-01-25 US disclosed
US-5972349-A COUPLING SACCHARIDE TO SOLID POLYETHYLENE GLYCOL MONOMETHYL ETHER SUPPORT, REMOVING FIRST PROTECTING GROUP, COUPLING WITH THE REPEATING UNIT UNTIL THE DESIRED NUMBER OF REPEATING UNITS IN THE OLIGOMER HAS BEEN REACHED, TERMINATING CONNAUGHT LABORATORIES LIMITED (CA) 1999-10-26 US disclosed
US-5679352-A Synthetic Haemophilus influenzae conjugate vaccine CONNAUGHT LABORATORIES LIMITED (CA) 1997-10-21 US disclosed
EP-0625203-A1 SYNTHETIC HAEMOPHILUS INFLUENZAE CONJUGATE VACCINE CONNAUGHT LABORATORIES LIMITED (CA) 1994-11-23 EP disclosed
WO-1993015205-A2 SYNTHETIC HAEMOPHILUS INFLUENZAE CONJUGATE VACCINE CONNAUGHT LABORATORIES LIMITED (CA) 1993-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230212178-A1 METHOD OF PRODUCING PHOTOREACTIVE NUCLEOTIDE ANALOG POLH, POLL, POLM TSHR 4018/4885
US-11214590-B2 Photoresponsive nucleotide analog capable of photocrosslinking in visible light region POLN, PCNA, POLL TSHR 3551/4885
US-11078211-B2 Photoresponsive nucleotide analog capable of photocrosslinking in visible light region PCNA, DCLRE1A, POLL TSHR 3740/4885
US-20200317685-A1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION PCNA, DCLRE1A, POLL TSHR 3740/4885
US-20200172563-A1 PHOTORESPONSIVE NUCLEOTIDE ANALOG CAPABLE OF PHOTOCROSSLINKING IN VISIBLE LIGHT REGION POLN, PCNA, POLL TSHR 3551/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.