Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | FPR3 | P25089 | 5/20 | 0.43 |
| ▸ | FPR2 | P25090 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061592 | 0.87 | P2RX7 (0.52) | P2RX7AKR1B1AKR1A1FPR3FPR2 | |
| SCHEMBL29925001 | 0.84 | EPHX2 (0.46) | FAAHMGLL | |
| SCHEMBL2732148 | 0.82 | FAAH (0.40) | CYP2C9CYP2C19FAAH | |
| SCHEMBL8061522 | 0.82 | P2RX7 (0.52) | P2RX7AKR1B1AKR1A1FPR3FPR2 | |
| SCHEMBL6496382 | 0.81 | ALDH1A1 (0.51) | — | |
| SCHEMBL18552880 | 0.80 | LMNA (0.45) | MTNR1BATM | |
| SCHEMBL7407182 | 0.79 | SMN1; SMN2 (0.53) | FPR2CYP2C9CYP2C19 | |
| SCHEMBL5729078 | 0.79 | EPHX2 (0.44) | CYP2C9CYP2C19FAAH | |
| SCHEMBL8062772 | 0.78 | KMT2A (0.49) | P2RX7AKR1B1AKR1A1CYP3A4CYP2C19 | |
| SCHEMBL29925442 | 0.78 | SMN1; SMN2 (0.43) | CYP2C9CYP2C19FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764634-B1 | N-(4-bromo-2-fluorobenzyl)carbamates and process for their preparation | CLARIANT GMBH (DE) | 2000-06-14 | — | — | EP | claimed |
| EP-0764634-A2 | N-(4-bromo-2-fluorobenzyl)carbamates and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-26 | — | — | EP | claimed |
| EP-1720836-B1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO [D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |
| EP-0764634-B1 | N-(4-bromo-2-fluorobenzyl)carbamates and process for their preparation | CLARIANT GMBH (DE) | 2000-06-14 | — | — | EP | disclosed |
| EP-0764634-A2 | N-(4-bromo-2-fluorobenzyl)carbamates and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-26 | — | — | EP | disclosed |