Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048326 | 0.90 | TP53 (0.37) | RAB9ANPC1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL8050861 | 0.84 | MAPT (0.32) | RAB9ANPC1SMN1; SMN2MAPTAGTR1 | |
| SCHEMBL8032541 | 0.84 | LMNA (0.33) | MAPTLMNA | |
| SCHEMBL8041804 | 0.82 | RAB9A (0.33) | RAB9ANPC1SMN1; SMN2MAPTAGTR1 | |
| SCHEMBL8042593 | 0.80 | ALDH1A1 (0.47) | RAB9ASMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL8042982 | 0.80 | KMT2A (0.35) | RAB9ANPC1SMN1; SMN2MAPTAGTR1 | |
| SCHEMBL8048329 | 0.79 | MAPT (0.36) | SMN1; SMN2MAPTAGTR1AGTR2ALDH1A1 | |
| SCHEMBL8043559 | 0.78 | MAPT (0.34) | NPC1MAPTALDH1A1 | |
| SCHEMBL8042872 | 0.76 | MAPT (0.33) | MAPTALDH1A1 | |
| SCHEMBL8033664 | 0.75 | RAB9A (0.39) | RAB9ANPC1SMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |