Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | POLA1 | P09884 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049873 | 0.86 | PPARD (0.42) | PPARDPOLA1CYP2C19KDM1AFFAR4 | |
| SCHEMBL8048882 | 0.86 | PPARD (0.42) | PPARDPOLA1CYP2C19KDM1AFFAR4 | |
| SCHEMBL8048886 | 0.86 | PPARD (0.42) | PPARDPOLA1CYP2C19KDM1AFFAR4 | |
| SCHEMBL8049867 | 0.86 | PPARD (0.42) | PPARDPOLA1CYP2C19KDM1AFFAR4 | |
| SCHEMBL8055650 | 0.84 | LMNA (0.43) | CYP2C19KDM1AMTNR1BESR1LMNA | |
| SCHEMBL8038058 | 0.78 | HSD17B1 (0.44) | CYP2C19KDM1AMTNR1AMTNR1BLMNA | |
| SCHEMBL7515670 | 0.77 | PPARD (0.38) | PPARDPOLA1CYP2C19FFAR4MTNR1A | |
| SCHEMBL11671496 | 0.72 | STS (0.60) | POLA1ESR1LMNAMAPTHSD17B1 | |
| SCHEMBL11222251 | 0.72 | STS (0.60) | POLA1ESR1LMNAMAPTHSD17B1 | |
| SCHEMBL8048425 | 0.72 | LMNA (0.56) | CYP2C19KDM1AESR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882735-B1 | 9 Alpha-hydroxy-8 alpha-estra-1,3,5(10)-trienes and a process for their preparation | JENAPHARM GMBH (DE) | 2000-04-19 | — | — | EP | disclosed |
| EP-0882735-A1 | 9 Alpha-hydroxy-8 alpha-estra-1,3,5(10)-trienes and a process for their preparation | Jenapharm GmbH & Co. KG (DE) | 1998-12-09 | — | — | EP | disclosed |