Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | ANTXR2 | P58335 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 3/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866851 | 0.77 | ESR1 (0.37) | ESR1ESR2GAAALDH1A1HPGD | |
| SCHEMBL16432837 | 0.76 | ELANE (0.46) | ELANEESR1ESR2ALDH1A1KDM4E | |
| SCHEMBL7358719 | 0.74 | RXRA (0.48) | ESR1ESR2GAAALDH1A1HPGD | |
| SCHEMBL29895902 | 0.74 | RXRA (0.48) | ESR1ESR2GAAALDH1A1HPGD | |
| SCHEMBL29150895 | 0.74 | ELANE (0.40) | ELANEANTXR2MAOAGAAHPGD | |
| SCHEMBL805313 | 0.74 | MAPT (0.50) | ELANEANTXR2MAOAGAAALDH1A1 | |
| SCHEMBL6175677 | 0.73 | PGAM1 (0.47) | MAOAGAAALDH1A1GLAKDM4E | |
| SCHEMBL17867292 | 0.73 | POLB (0.41) | ELANEESR1ESR2GAAALDH1A1 | |
| SCHEMBL29895904 | 0.73 | ESR1 (0.35) | ELANEESR1ESR2GAAALDH1A1 | |
| SCHEMBL7963459 | 0.72 | ALDH1A1 (0.45) | ESR1ESR2GAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2017-06-08 | — | — | US | disclosed |
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | THE GENERAL HOSPITAL CORPORATION (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120070369-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | ELANE 1449/4885ANTXR2 1573/4885ESR1 1246/4885 |
| US-20170157111-A1 | HIF INHIBITORS AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | ELANE 1449/4885ANTXR2 1573/4885ESR1 1246/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.