Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.69 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | CTSG | P08311 | 1/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.54 |
| ▸ | CMA1 | P23946 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3192014 | 0.82 | LMNA (0.77) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL496789 | 0.81 | SMN1; SMN2 (0.81) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL5948102 | 0.81 | EPHX2 (1.00) | EPHX2NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL13862225 | 0.81 | NPC1 (0.62) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL28767455 | 0.80 | EPHX2 (0.67) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL28152983 | 0.80 | EPHX2 (0.61) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL27389698 | 0.79 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8851563 | 0.79 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL28242822 | 0.79 | EPHX2 (0.75) | EPHX2NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL27790062 | 0.79 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092790-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092790-A1 | DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, RHOA | EPHX2 668/4885NPC1 1946/4885RAB9A 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.