Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.67 |
| ▸ | CA1 | P00915 | 10/20 | 0.67 |
| ▸ | CA9 | Q16790 | 7/20 | 0.57 |
| ▸ | CA12 | O43570 | 6/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.57 |
| ▸ | CA4 | P22748 | 3/20 | 0.57 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA5A | P35218 | 3/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964478 | 0.98 | CA2 (0.70) | CA2CA1CA9CA12CA14 | |
| SCHEMBL8054962 | 0.96 | CA2 (0.67) | CA2CA1CA9CA12CA14 | |
| SCHEMBL2398133 | 0.81 | CA2 (1.00) | CA2CA1CA9CA12CA14 | |
| SCHEMBL31435391 | 0.79 | AKR1B1 (0.56) | MEN1KMT2AALDH1A1PGRMMP2 | |
| SCHEMBL2199161 | 0.79 | AKR1B1 (0.56) | MEN1KMT2AALDH1A1PGRMMP2 | |
| SCHEMBL29960292 | 0.77 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1PGRMMP2 | |
| SCHEMBL29422524 | 0.77 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1PGRMMP2 | |
| SCHEMBL294451 | 0.77 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1PGRMMP2 | |
| SCHEMBL294450 | 0.77 | PGR (0.53) | MEN1KMT2AALDH1A1PGRMAPT | |
| SCHEMBL8477676 | 0.77 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1PGRMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1086578-C | Sulfonamides and their use | HOFFMANN LA ROCHE (CH) | 2002-06-26 | — | — | CN | disclosed |
| US-6030976-A | SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE | HOFFMAN-LA ROCHE INC. (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998665-A | THERAPY FOR NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-12-07 | — | — | US | disclosed |
| US-5939451-A | INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-17 | — | — | US | disclosed |
| US-5932599-A | 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-08-03 | — | — | US | disclosed |
| CN-1170574-A | Sulfonamides and their use | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | CN | disclosed |