Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11810775 | 0.85 | HSP90AA1 (0.55) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL18216913 | 0.79 | L3MBTL1 (0.54) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL14164034 | 0.78 | ALDH1A1 (0.49) | HSP90AA1CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL12697515 | 0.76 | CYP1A2 (0.49) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL17993428 | 0.76 | L3MBTL1 (0.61) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL6172768 | 0.76 | CYP1A2 (0.49) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL3894503 | 0.76 | HSP90AA1 (0.71) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL18939743 | 0.75 | GAA (0.59) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL11286099 | 0.74 | KMT2A (0.56) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 | |
| SCHEMBL10646087 | 0.74 | HSP90AA1 (0.46) | HSP90AA1CYP1A2CYP3A4CYP2D6CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
| US-7691853-B2 | Pyrazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | HSP90AA1 4129/4885CYP1A2 3042/4885CYP3A4 2929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.