Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.53 |
| ▸ | CA9 | Q16790 | 7/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8056514 | 0.78 | NPC1 (0.45) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL8062947 | 0.76 | CA12 (0.36) | CA12CA9CA2CA7CA14 | |
| SCHEMBL8060804 | 0.75 | CYP2C9 (0.46) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL5904274 | 0.75 | PTPRC (0.47) | CA12CA9CA2CA1CA7 | |
| SCHEMBL10734283 | 0.75 | CA12 (0.64) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL8057027 | 0.74 | RAB9A (0.43) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL30726848 | 0.74 | CA12 (0.56) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL8045354 | 0.73 | ALOX5 (0.43) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL29070078 | 0.73 | CYP2C9 (0.45) | CA12CA9ALOX5CA2CA1 | |
| SCHEMBL8062932 | 0.72 | TRPA1 (0.44) | CA12CA9ALOX5CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028069-A | Heterocyclyl-condensed benzoylguanidines, their production and use as inhibitors of the cellular Na+/H+-antiporter | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |