Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3027043 | 0.99 | CHRNB2 (0.44) | CHRNB2CHRNA4PRCPHTR2BHTR2C | |
| Hydrochloric Acid SCHEMBL3027041 | 0.99 | CHRNB2 (0.44) | CHRNB2CHRNA4PRCPHTR2BHTR2C | |
| Hydrochloric Acid SCHEMBL3027045 | 0.99 | CHRNB2 (0.44) | CHRNB2CHRNA4PRCPHTR2BHTR2C | |
| SCHEMBL8070678 | 0.85 | CHRNB2 (0.36) | CHRNB2CHRNA4HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL3028782 | 0.83 | HTR2C (0.36) | CHRNB2CHRNA4HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL3028775 | 0.83 | HTR2C (0.36) | CHRNB2CHRNA4HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL3028776 | 0.83 | HTR2C (0.36) | CHRNB2CHRNA4HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL3024997 | 0.82 | ADRA1A (0.32) | CHRNB2CHRNA4HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL3025004 | 0.82 | ADRA1A (0.32) | CHRNB2CHRNA4HTR2BHTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL3024999 | 0.82 | ADRA1A (0.32) | CHRNB2CHRNA4HTR2BHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100210680-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2010-08-19 | — | — | US | disclosed |
| US-20100210680-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON | 2010-08-19 | — | — | US | disclosed |
| WO-2009037220-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | N.V. ORGANON (NL) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210680-A1 | TRICYCLIC HETEROCYCLIC DERIVATIVES | TPH1, HTR2C, TPH2 | CHRNB2 265/4885CHRNA4 131/4885PRCP 1426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.