SCHEMBL8057091

SCHEMBL8057091

COC(=O)c1c(Cl)ccc2nnsc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BAZ1A Q9NRL2 1/20 0.41
NSD2 O96028 2/20 0.40
MAPT P10636 6/20 0.38
POLB P06746 3/20 0.38
BLM P54132 1/20 0.38
NOTUM Q6P988 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TP53 P04637 1/20 0.36
THRB P10828 1/20 0.36
GAA P10253 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9087697 0.82 MAPT (0.40) NSD2MAPTPOLBBLMMEN1
SCHEMBL9668300 0.81 DPP4 (0.44) BAZ1AMAPTPOLBMEN1KMT2A
SCHEMBL9668093 0.72 BAZ1A (0.40) BAZ1ANSD2MAPTPOLBMEN1
SCHEMBL8603908 0.69 GAA (0.38) MAPTMEN1KMT2ASMN1; SMN2TP53
SCHEMBL8466456 0.69 LCK (0.56) NSD2MAPTPOLBBLMMEN1
SCHEMBL7288400 0.68 CA12 (0.53) MAPTMEN1KMT2ASMN1; SMN2TP53
SCHEMBL543109 0.68 PLA2G2A (0.44) MAPTMEN1KMT2ASMN1; SMN2TP53
1,2,3-Benzothia-Diazole-7-Carboxylic Acid SCHEMBL8588144 0.68 MAPT (0.45) MAPTPOLBMEN1KMT2ASMN1; SMN2
SCHEMBL16702234 0.68 ALDH1A1 (0.60) POLBMEN1KMT2ASMN1; SMN2GAA
SCHEMBL16808738 0.68 DPP4 (0.57) POLBMEN1KMT2ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0502473-B1 Microbicidal benzo-1,2,3-thiadiazole derivatives NOVARTIS AG (CH) 2000-04-26 EP disclosed
US-5384321-A Benzothiadiazole compounds CIBA-GEIGY CORPORATION (US) 1995-01-24 US disclosed
US-5304652-A Benzo-1,2,3-thiadiazole derivatives; fungicides CIBA-GEIGY CORPORATION (US) 1994-04-19 US disclosed
EP-0420803-B1 Benzo-1,2,3-thiadiazole derivatives and their use for protecting plants against diseases CIBA GEIGY AG (CH) 1994-03-09 EP disclosed
US-5260423-A Fungicide, viricide or bactericide CIBA-GEIGY CORPORATION (US) 1993-11-09 US disclosed
US-5229384-A Microbiocides CIBA-GEIGY CORPORATION (US) 1993-07-20 US disclosed
EP-0502473-A1 Microbicidal benzo-1,2,3-thiadiazole derivatives CIBA-GEIGY AG (CH) 1992-09-09 EP disclosed
EP-0420803-A2 Benzo-1,2,3-thiadiazole derivatives and their use for protecting plants against diseases CIBA-GEIGY AG (CH) 1991-04-03 EP disclosed