Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | INMT | O95050 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623976 | 0.88 | — | — | |
| Acrylic Acid SCHEMBL5216290 | 0.84 | LMNA (0.43) | CYP1A2ALDH1A1LMNAALOX15HSD17B10 | |
| Maleic Acid SCHEMBL1072943 | 0.81 | HCAR2 (0.36) | TSHRTP53EGLN1EGLN3CYP1A2 | |
| Vinyl Chloride SCHEMBL2305839 | 0.80 | — | — | |
| Methacrylic Acid SCHEMBL7855533 | 0.76 | LMNA (0.31) | TSHRLMNA | |
| SCHEMBL3151880 | 0.75 | HCAR2 (0.40) | ALDH1A1HTTMAPTHCAR2ALOX15 | |
| SCHEMBL757738 | 0.73 | POLB (0.35) | TSHRCYP1A2ALDH1A1MAPTNPSR1 | |
| SCHEMBL765594 | 0.73 | — | — | |
| Maleic Acid SCHEMBL9579937 | 0.72 | HCAR2 (0.36) | TSHRTP53EGLN1EGLN3HCAR2 | |
| Monomethyl Fumarate SCHEMBL3148636 | 0.72 | HCAR2 (0.68) | TSHRTP53EGLN1EGLN3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6051643-A | Resin composite and method for producing the same | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 2000-04-18 | — | — | US | disclosed |