Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7644621 | 0.85 | FFAR1 (0.42) | FFAR1PPARGPPARAKMT2A | |
| SCHEMBL7642964 | 0.84 | CPA3 (0.55) | FFAR1 | |
| SCHEMBL7650843 | 0.83 | FOLH1 (0.44) | FFAR1PPARGPPARAKMT2AHTT | |
| SCHEMBL5059934 | 0.81 | FFAR1 (0.46) | LDHAFFAR1KMT2AL3MBTL1PDE4B | |
| SCHEMBL31650242 | 0.75 | LDHA (0.60) | LDHAFFAR1PPARGPPARAPDE4B | |
| SCHEMBL7653675 | 0.74 | CPA3 (0.47) | SMN1; SMN2 | |
| SCHEMBL5054341 | 0.73 | MTNR1B (0.44) | KMT2ANPC1RAB9A | |
| SCHEMBL27542987 | 0.72 | LDHA (0.57) | LDHAFFAR1PPARGPPARAL3MBTL1 | |
| SCHEMBL21986448 | 0.72 | CPA3 (0.41) | FFAR1 | |
| SCHEMBL7036604 | 0.71 | KEAP1 (0.47) | FFAR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025344-A | NOVEL PHOSPHONATE DERIVATIVES, HYDROXYPHOSPHINYL DERIVATIVES, AND PHOSPHORAMIDATE DERIVATIVES THAT INHIBIT N-ACETYLATED .ALPHA.-LINKED ACIDIC DIPEPTIDASE (NAALADASE) ENZYME ACTIVITY, | GUILFORD PHARMACEUTICALS INC. (US) | 2000-02-15 | — | — | US | claimed |