Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78114 | 0.86 | PTGS2 (0.49) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL79838 | 0.84 | PTGS2 (0.51) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL4729843 | 0.84 | PTGS2 (0.68) | PTGS2 | |
| SCHEMBL11667339 | 0.81 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL78354 | 0.80 | PTGS2 (0.48) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL11343630 | 0.79 | ALDH1A1 (0.49) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL77537 | 0.79 | ALDH1A1 (0.46) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL79387 | 0.79 | ALDH1A1 (0.46) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL78629 | 0.78 | PTGS2 (0.54) | PTGS2ALDH1A1PGRGAAPTGS1 | |
| SCHEMBL78292 | 0.78 | ALDH1A1 (0.48) | PTGS2ALDH1A1PGRGAAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618162-B2 | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120122970-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2012-05-17 | — | — | US | disclosed |
| US-8129428-B2 | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| WO-2009036235-A2 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (ACHE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20090068242-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2009-03-12 | — | — | US | disclosed |
| EP-0010580-B1 | 2-(1-METHYL-PROPYN-2-YL-THIO)-PHENYL-N-METHYLCARBAMATE, PROCESS FOR ITS PREPARATION AND ITS USE IN COMBATING PESTS | BASF Aktiengesellschaft (DE) | 1982-09-29 | — | — | EP | disclosed |
| US-4239775-A | 2-(1-Methylpropyn-2-yl-thio)-phenyl-N-methylcarbamate and its use for combating pests of the Acarina order | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-16 | — | — | US | disclosed |
| EP-0010580-A1 | 2-(1-Methyl-propyn-2-yl-thio)-phenyl-N-methylcarbamate, process for its preparation and its use in combating pests | BASF Aktiengesellschaft (DE) | 1980-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068242-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | ACHE, BCHE, CHAT | PTGS2 2891/4885ALDH1A1 960/4885PGR 3222/4885 |
| US-20120122970-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | ACHE, BCHE, CHAT | PTGS2 2891/4885ALDH1A1 960/4885PGR 3222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.