Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 20/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11667339 | 0.84 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL80588 | 0.84 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL942835 | 0.79 | PTGS2 (0.64) | PTGS2 | |
| SCHEMBL27044926 | 0.79 | PTGS2 (0.69) | PTGS2 | |
| SCHEMBL10647305 | 0.78 | MTNR1A (0.50) | PTGS2 | |
| SCHEMBL14273054 | 0.78 | PTGS2 (0.79) | PTGS2 | |
| SCHEMBL8854000 | 0.78 | L3MBTL1 (0.40) | PTGS2 | |
| SCHEMBL14273053 | 0.78 | PTGS2 (0.68) | PTGS2 | |
| SCHEMBL13659627 | 0.77 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL6535129 | 0.76 | PTGS2 (1.00) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210196731-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR INFLAMMATION AND OCULAR SCARRING | ARMSTRONG JAMES JACOB BRUVALL (CA) | 2021-07-01 | — | — | US | disclosed |
| EP-3801624-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR INFLAMMATION AND OCULAR SCARRING | Armstrong, James Jacob Bruvall (CA) | 2021-04-14 | — | — | EP | disclosed |
| WO-2019227207-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR INFLAMMATION AND OCULAR SCARRING | ARMSTRONG JAMES JACOB BRUVALL (CA) | 2019-12-05 | — | — | WO | disclosed |
| WO-2014015341-A2 | COMPOSITIONS AND METHODS FOR SUBSTRATE-SELECTIVE INHIBITION OF ENDOCANNABINOID OXYGENATION | VANDERBILT UNIVERSITY (US) | 2014-01-23 | — | — | WO | disclosed |
| EP-1476149-B1 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | UNIV TEMPLE (US) | 2008-08-06 | — | — | EP | disclosed |
| US-RE39681-E1 | 1-(4-sulfamyaryl)-3-substituted-5-aryl-2-pyrazolines and inhibitors of cyclooxygenase-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-06-05 | — | — | US | disclosed |
| EP-1191931-B1 | 1-(4-SULFAMYLPHENYL)-3-TRIFLUOROMETHYL-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | UNIV TEMPLE (US) | 2007-05-09 | — | — | EP | disclosed |
| US-20070066651-A1 | Pyrazoline derivatives useful for the treatment of cancer | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2007-03-22 | — | — | US | disclosed |
| US-7122571-B2 | Substituted hydrazones as inhibitors of cyclooxygenase-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-10-17 | — | — | US | disclosed |
| EP-1476149-A4 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | UNIV TEMPLE (US) | 2005-09-14 | — | — | EP | disclosed |
| US-6656968-B1 | Selectively inhibit the cyclooxygenase activity of COX-2 over COX-1; addition polymers of compound | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |
| US-20030187035-A1 | Substituted hydrazones as inhibitors of cyclooxygenase-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-10-02 | — | — | US | disclosed |
| WO-2003049698-A2 | SUBSTITUTED HYDRAZONES AS INHIBITORS OF CYCLOOXYGENASE-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2003-06-19 | — | — | WO | disclosed |
| EP-1191931-A4 | 1-(4-SULFAMYLARYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | UNIV TEMPLE (US) | 2002-11-27 | — | — | EP | disclosed |
| US-6376519-B1 | ANTIINFLAMMATORY AGENTS, ANTICANCER AGENTS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH OF HIGHER EDUCATION | 2002-04-23 | — | — | US | disclosed |
| EP-1191931-A1 | 1-(4-SULFAMYLARYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | Temple University of the Commonwealth System of Higher Education (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-1191929-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | Temple University of the Commonwealth System of Higher Education (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077169-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000076503-A1 | 1-(4-SULFAMYLARYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |
| WO-2000076983-A1 | 1-(4-ARYLSULFONYL)-3-SUBSTITUTED-5-ARYL-2-PYRAZOLINES AS INHIBITORS OF CYCLOOXYGENASE-2 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187035-A1 | Substituted hydrazones as inhibitors of cyclooxygenase-2 | PTGS1, PTGS2, PTGES2 | PTGS2 2/4885 |
| US-20070066651-A1 | Pyrazoline derivatives useful for the treatment of cancer | PTGIS, PTGS1, PTGIR | PTGS2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.