Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046498 | 0.92 | TBXAS1 (0.50) | FDPSCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8058443 | 0.91 | TBXAS1 (0.52) | FDPSCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8058455 | 0.86 | CYP1A2 (0.56) | FDPSCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8058495 | 0.85 | SMN1; SMN2 (0.40) | CYP1A2CYP3A4CYP2C9CYP2C19HIF1A | |
| SCHEMBL7644315 | 0.76 | GRM2 (0.44) | — | |
| SCHEMBL8059183 | 0.76 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8059180 | 0.75 | GRM2 (0.45) | — | |
| SCHEMBL27397456 | 0.74 | FDPS (0.60) | FDPSCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8046670 | 0.73 | KCNA5 (0.39) | FDPSCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8506198 | 0.73 | FDPS (0.55) | FDPSCYP1A2CYP3A4CYP2C9TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |