SCHEMBL8046670

SCHEMBL8046670

O=C(O)C(Cc1ccncc1)(c1ccccc1)[PH](=O)O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 1/20 0.39
CYP19A1 P11511 1/20 0.39
FDPS P14324 1/20 0.38
ALDH1A1 P00352 2/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
HIF1A Q16665 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HTT P42858 2/20 0.37
KIF11 P52732 1/20 0.37
CYP1A2 P05177 4/20 0.37
CYP2C9 P11712 4/20 0.37
CYP2C19 P33261 4/20 0.37
CYP3A4 P08684 3/20 0.37
CYP2D6 P10635 2/20 0.37
PLOD2 O00469 1/20 0.37
PLOD3 O60568 1/20 0.37
HPGD P15428 1/20 0.37
PLOD1 Q02809 1/20 0.37
ALPL P05186 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8058495 0.85 SMN1; SMN2 (0.40) CYP19A1ALDH1A1GAAMAPTHIF1A
SCHEMBL8058455 0.84 CYP1A2 (0.56) KCNA5FDPSHIF1ACYP1A2CYP2C9
SCHEMBL8057354 0.78 FDPS (0.44) FDPSALDH1A1GAASMN1; SMN2CYP1A2
SCHEMBL8058563 0.77 GRM2 (0.39) MAPTHIF1ASMN1; SMN2CHRM2CHRM1
SCHEMBL8059273 0.75 CYP2C19 (0.41) ALDH1A1SMN1; SMN2CYP2C9CYP2C19HPGD
SCHEMBL8059121 0.73 FDPS (0.47) KCNA5FDPSHIF1ACYP1A2CYP2C9
SCHEMBL8046498 0.72 TBXAS1 (0.50) KCNA5FDPSHIF1ACYP1A2CYP2C9
SCHEMBL8058443 0.71 TBXAS1 (0.52) FDPSHIF1ACYP1A2CYP2C9CYP2C19
SCHEMBL7644315 0.70 GRM2 (0.44) MAPTSMN1; SMN2
SCHEMBL15405153 0.70 CYP1A2 (0.73) KCNA5CYP19A1FDPSALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046180-A NAALADase inhibitors GUILFORD PHARMACEUTICALS INC. (US) 2000-04-04 US disclosed
EP-0936914-A4 1999-08-25 EP disclosed
EP-0936914-A1 HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 1999-08-25 EP disclosed
WO-1997048400-A1 HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS GUILFORD PHARMACEUTICALS INC. (US) 1997-12-24 WO disclosed