Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8058494 | 0.86 | CYP2C19 (0.40) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL8058563 | 0.75 | GRM2 (0.39) | SMN1; SMN2POLBTDP1SLC1A3SLC1A2 | |
| SCHEMBL8046670 | 0.75 | KCNA5 (0.39) | CYP2C19HPGDSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL28823525 | 0.74 | CYP2C19 (0.45) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL28997198 | 0.72 | CYP2C19 (0.53) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL28013234 | 0.72 | RIPK1 (0.43) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL27569205 | 0.71 | POLB (0.46) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL27988728 | 0.71 | CYP2C19 (0.52) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL27480004 | 0.71 | CYP2C19 (0.52) | CYP2C19HPGDLMNASMN1; SMN2RAB9A | |
| SCHEMBL8057354 | 0.71 | FDPS (0.44) | CYP2C19HPGDLMNASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046180-A | NAALADase inhibitors | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0936914-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0936914-A4 | — | — | 1999-08-25 | — | — | EP | disclosed |
| WO-1997048400-A1 | HYDROXY-PHOSPHINYL DERIVATIVES USEFUL AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | disclosed |