Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 6/20 | 0.38 |
| ▸ | MMP8 | P22894 | 6/20 | 0.38 |
| ▸ | MMP12 | P39900 | 6/20 | 0.38 |
| ▸ | MMP13 | P45452 | 6/20 | 0.38 |
| ▸ | MMP14 | P50281 | 6/20 | 0.38 |
| ▸ | MMP16 | P51512 | 6/20 | 0.38 |
| ▸ | MMP9 | P14780 | 5/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540134 | 0.82 | KDM4E (0.47) | MEN1KMT2ASLC22A12ABCC9ABCC8 | |
| SCHEMBL7534915 | 0.77 | KDM4E (0.52) | MEN1KMT2AMMP2MMP8MMP12 | |
| SCHEMBL7535488 | 0.74 | MEN1 (0.49) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL7533901 | 0.72 | LMNA (0.52) | MMP2MMP8MMP12MMP13MMP14 | |
| SCHEMBL7533132 | 0.70 | LMNA (0.50) | MEN1KMT2ASLC22A12ABCC9ABCC8 | |
| SCHEMBL7540327 | 0.68 | POLB (0.50) | KMT2ASLC22A12 | |
| SCHEMBL7535538 | 0.67 | PKM (0.56) | SLC22A12TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7813282 | 0.67 | LMNA (0.55) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL7540150 | 0.67 | MAPT (0.58) | MEN1KMT2AABCC9ABCC8KCNJ11 | |
| SCHEMBL12504669 | 0.66 | ACLY (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005453-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK, INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1999010320-A1 | SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS | TULARIK INC. (US) | 1999-03-04 | — | — | WO | claimed |