Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539317 | 0.91 | HSD11B1 (0.49) | KMT2AMEN1ALDH1A1HSD11B1LMNA | |
| SCHEMBL8048283 | 0.90 | SMN1; SMN2 (0.42) | KMT2AALDH1A1LMNAGAADPP4 | |
| SCHEMBL8058688 | 0.89 | KMT2A (0.45) | KMT2AMEN1LMNAGAAPOLB | |
| SCHEMBL8053303 | 0.87 | HSD11B1 (0.52) | KMT2AMEN1ALDH1A1HSD11B1LMNA | |
| SCHEMBL4539809 | 0.87 | HSD11B1 (0.52) | KMT2AMEN1ALDH1A1HSD11B1LMNA | |
| SCHEMBL8063498 | 0.87 | POLB (0.39) | LMNAHTTTSHRALOX12NPSR1 | |
| SCHEMBL8058685 | 0.84 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL4542374 | 0.81 | HSD11B1 (0.53) | KMT2AMEN1ALDH1A1HSD11B1LMNA | |
| SCHEMBL4537048 | 0.81 | LMNA (0.47) | KMT2AMEN1LMNAGAAUSP2 | |
| SCHEMBL4537343 | 0.80 | LMNA (0.59) | KMT2AMEN1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |