Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053303 | 1.00 | HSD11B1 (0.52) | HSD11B1LMNAUSP2TSHRALOX12 | |
| SCHEMBL4539317 | 0.95 | HSD11B1 (0.49) | HSD11B1LMNAUSP2TSHRALOX12 | |
| SCHEMBL4542374 | 0.94 | HSD11B1 (0.53) | HSD11B1LMNAUSP2TSHRALOX12 | |
| SCHEMBL4537257 | 0.88 | LMNA (0.51) | HSD11B1LMNAUSP2TSHRALOX12 | |
| SCHEMBL4539985 | 0.88 | TSHR (0.50) | HSD11B1LMNAUSP2TSHRALOX12 | |
| SCHEMBL4536776 | 0.88 | LMNA (0.62) | LMNAUSP2TSHRALOX12HTT | |
| SCHEMBL4540431 | 0.88 | NPC1 (0.55) | LMNAUSP2TSHRALOX12HTT | |
| SCHEMBL8059966 | 0.87 | KMT2A (0.42) | HSD11B1LMNAUSP2TSHRALOX12 | |
| SCHEMBL4537706 | 0.87 | EPHX2 (0.48) | LMNAUSP2EPHX1KMT2ASMN1; SMN2 | |
| SCHEMBL4540068 | 0.87 | EPHX1 (0.54) | HSD11B1LMNAUSP2TSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |